CLINICAL MANIFESTATIONS, SUBCLINICAL HARACTERISTICS AND COMPLICATIONS OF MEASLES IN PREGNANT WOMEN: A RETROSPECTIVE STUDY IN VIET NAM

Tóm tắt

Measles outbreaks still represents a serious public health problem in developing
countries. There are few reports of measles in pregnant women in the contemporary
literature. The study aimed to describe clinical features subclinical findings and
complications of hospitalized measles pregnancy women in Vietnam, in comparison
with non-pregnancy women.
All pregnant women hospitalized with measles at the National Hospital for
Tropical Diseases, Ha Noi, Northern Vietnam from July 2015 to June 2020 were
included. Demographic, clinical manifestations, laboratory findings, and
complications data were analyzed.
Of 98 hospitalized women, the mean time before the rash eruption and that of
symptoms before hospital admission in the group of pregnant women were 3.5 and
4.0 days, which were lower than those of the non-pregnant women group with 4.1
and 4.8 days (p = 0.009 and p = 0.004, respectively). Measles rash in the pregnant
women group was higher than that of the non-pregnant group with (87.8% vs.
81.6%; p>0.05). The data of Koplic spot in pregnant women with measles was 34.7%
and that of cough symptom was 85.7%. Corresponding in non-pregnant female
patients were 28.6% and 83.7%, respectively (p < 0.05). The mean CRP value in the
pregnant group was higher than that of the non-pregnant group (54.1 mg/L versus
26.9 mg/L, p < 0.05). The percentage of pregnant women infected with measles with
respiratory complications was higher than that of no-pregnancy women (65.3% vs.
44.9%, p = 0.042). The CRP value ≥ 94.5 mg/l was associated with pneumonia in
pregnant women infected with measles (p<0.05; OR 31.2, 95% CI: 2.9 – 337.4).
Pneumonitis was the most common complication in pregnant women with
measles when compared to non-pregnant women. The level of CRP in combination
with other subclinical findings was also a vital marker in predicting complications of
pregnancy with measles disease